Introduction. In this context, we discuss the use of a ciprofloxacin/cemetacab chloride combination to treat a range of bacterial infections of the urinary tract. We review the evidence on the potential impact that this combination has on the incidence and severity of infections. We also discuss the potential risks and benefits of using this combination in patients.
MethodsWe conducted a systematic literature review using the MEDLINE (1966-February 2020) and CINAHL (1974-February 2020) databases with the keywords ‘ciprofloxacin/cemetacab’ and ‘ciprofloxacin/cemetacab’.
ResultsWe found a clear evidence for this combination in the overall infection rate, regardless of the type of infection (e.g. UTI, bacterial endocarditis). We did not find any evidence that this combination significantly impacts the rates of infection (e.g. UTI incidence, bacterial endocarditis). However, we concluded that the combination was safe to use in a patient with a history of UTI and bacterial endocarditis. We used the database to identify the most common infection among patients with UTI and bacterial endocarditis.
ConclusionsOur findings suggest that a ciprofloxacin/cemetacab chloride combination is associated with an increased risk of bacterial infections and severity. However, future studies need to address the specific issue of its efficacy and safety.
Bacterial infections of the urinary tract (UTIs) account for more than 20% of all UTIs and account for over $2 billion annually worldwide. Bacterial infections of the urethra, bladder, and lower urinary tract account for less than $1 billion of this expenditure.
This review aims to examine the available evidence on the efficacy and safety of a ciprofloxacin/cemetacab combination in the treatment of bacterial infections of the urinary tract. The review also highlights the risks and benefits of using this combination in patients.
The use of ciprofloxacin/cemetacab, or ciprofloxacin, and other antimicrobial agents has been investigated as effective options for the treatment of UTIs in both humans and animals []. However, it is still a topic of debate regarding the potential impact that this combination has on the incidence and severity of UTIs. The risk of developing infection, however, is still unclear in humans. Studies have found no evidence that the combination of ciprofloxacin/cemetacab or other drugs used to treat UTIs, including antibiotics, caused a significant increase in the frequency or severity of UTIs. These studies have not been designed to specifically examine the potential impact on the incidence or severity of UTIs.
In recent years, there has been an increasing concern about the potential impact that the use of ciprofloxacin/cemetacab can have on the incidence and severity of UTIs in humans and animals. This concern is particularly true for the use of ciprofloxacin and other antibiotics []. Although ciprofloxacin has been shown to have a lower incidence of UTIs in humans, a large study by Chen et al. [] found no evidence that the combination of ciprofloxacin and antibiotics used to treat UTIs were associated with an increased risk of UTIs. This finding led the US Centers for Disease Control and Prevention (CDC) to recommend that antibiotics should not be used in the treatment of UTIs [].
The ciprofloxacin/cemetacab combination is a drug used to treat bacterial infections and is also an effective antibiotic for bacterial infections. Ciprofloxacin has been shown to be effective in the treatment of UTIs and a small amount of cases have been reported []. Ciprofloxacin is known to inhibit protein synthesis in most of the gram-positive bacteria []. The ciprofloxacin/cemetacab combination is well tolerated with some patients experiencing side effects. Ciprofloxacin may be used to treat UTIs, but it has not been shown to have a significant impact on the incidence or severity of UTIs.
In addition to the use of ciprofloxacin/cemetacab as an effective agent for UTIs, there have also been reports of the potential effects of the combination on the incidence and severity of UTIs.
Treatment of bacterial infections of the lungs, nose, ear, bones and joints, skin and soft tissue, kidney, bladder, abdomen, and genitals caused by ciprofloxacin-susceptible organisms. Infections may include urinary tract infection, prostatitis, lower respiratory tract infection, otitis media (middle ear infection), sinusitis, skin, bone and joint infections, infectious diarrhea, typhoid fever, and gonorrhea.
May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.
Hypersensitivity to ciprofloxacin or other quinolones. History or risk of QT prolongation; known history of myasthenia gravis. Concomitant use with tizanidine.
Vomiting, Stomach pain, Nausea, Diarrhea
Patient with known or suspected CNS disorders, risk factors predisposing to seizures, or lower seizure threshold; history or risk factors for QT interval prolongation, torsades de pointes, uncorrected hypokalaemia/hypomagnesaemia, cardiac disease (e.g. heart failure, MI, bradycardia); positive family history of aneurysm disease, pre-existing aortic aneurysm or dissection and its risk factors (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, hypertension, peripheral atherosclerotic vascular disease); diabetes, previous tendon disorder (e.g. rheumatoid arthritis), G6PD deficiency. Renal and hepatic impairment. Elderly, children. Pregnancy and lactation.
Store between 20-25°C.
Quinolones
uses a class of drugs called quinolones. They are highly protein-bound, and their activity is restricted to the kidneys. This means that they are more likely to be effective in respiratory tract infections. Their use is not recommended in pregnant women.AtypicalCiprofloxacin
co-amoxiclav
Hypersensitivity to quinolones or other quinolones.
Ciprofloxacin should not be taken if you have had an allergic reaction to ciprofloxacin, other quinolones, cephalosporin or other antibiotics. Therefore, do not take ciprofloxacin if you are allergic to ciprofloxacin-susceptible organisms. Also, do not take ciprofloxacin with iron, zinc or magnesium salts. Avoid using other medications that may interact with ciprofloxacin. Patients with renal or hepatic impairment should not take this medicine.
The most common side effects are gastrointestinal, with nausea, vomiting, loss of appetite, bone and joint pains, headache, vomiting and pain. Allergic reactions such as skin rash, itching or hives, swelling of the face, lips, tongue, throat or other parts of the body may also occur. Caution is advised when using this medicine because of the risk of QT prolongation. Patients with pre-existing aortic aneurysm or dissection may also experience side effects.
This medication is not for use if you are allergic to ciprofloxacin, or any of the ingredients in the medication. Ask your doctor about the risks and benefits if you are pregnant or may become pregnant. If your doctor approves ciprofloxacin, discuss with you how to take this medication and how to monitor for side effects.
Tell your doctor if you have liver problems, a kidney disorder (such as nephritis, which is high on the general population), or a heart condition such as chest pain, shortness of breath, or irregular heartbeat. Ciprofloxacin can cause a life-threatening condition called pseudotumor cerebri, or pustulosis, which causes severe headaches, nausea, vomiting, diarrhea, and sometimes, a loss of appetite. If you have these symptoms, stop taking this medication and call your doctor right away.
Some common side effects of taking ciprofloxacin are diarrhea, stomach upset, or a rash. If these side effects bother you or do not go away, talk with your doctor. Your doctor will probably tell you not to take ciprofloxacin if you are pregnant or may become pregnant. Ciprofloxacin passes in your body. Do not take ciprofloxacin if you are breast-feeding.
Ciprofloxacin can cause other side effects. Talk to your doctor about all the possible side effects. You may not benefit from taking this medication or other types of antibiotics if you have kidney problems.
If you are breast-feeding, it is not recommended to take this medication unless your doctor advises you to do so. Ciprofloxacin passes into breast milk.
Ciprofloxacin may not be safe for you or a family member who has a history of allergy to ciprofloxacin or any other components of this medication. Ask your doctor about the risks if you are breast-feeding.
Before taking ciprofloxacin, tell the doctor or pharmacist if you are allergic to any other drugs, foods, dyes, preservatives, or preservatives other than those listed below. Ciprofloxacin is not approved for use in children under age 6. Ciprofloxacin is not approved for use in children under age 6 and is not for use in pregnant women, women who cannot take birth control pills, women who cannot take birth control pills, women who are breast-feeding, or women who are taking hormonal birth control pills. Ciprofloxacin is not approved for use in women who cannot take birth control pills.
Ciprofloxacin tablet (ciprofloxacin tablet) may not be safe for use during pregnancy. You may get certain side effects. Tell your doctor if you are pregnant or plan to become pregnant.This medication may cause other side effects. Tell your doctor if you have any new or worsening side effects. Your doctor may need to check your breasts for a change in your menstrual pattern.Tell your doctor if you are breastfeeding.
Ciprofloxacin may cause other side effects. Ask your doctor if you have any side effects that bother you or you may not benefit from taking this medication. Call your doctor if your symptoms do not improve or if they become worse.
The following are some common side effects of taking ciprofloxacin. You may not benefit from taking ciprofloxacin or other medications.
Call your doctor if you get any of the following:
Cipro has been shown to cause some side effects. Talk to your health care provider if these mild reactions do not go away within a few days.
Common side effects reported from Cipro use include:
This is not a complete list of adverse reactions caused by Cipro.Call your doctor immediately if you experience the following:
Taking Cipro has been shown to impact your tendons (cords attaching bone to your muscles). It can increase your risk of developing tendonitis or a tendon rupture, especially if you’re over 60, taking steroid medications, or have a history of tendon problems.
Cipro can interact with other medications and substances, causing potentially serious side effects or allergic reactions. Tell your doctor if you are taking muscle relaxers such as tizanidine (Zanaflex), phosphodiesterase 5 (PDE5) inhibitors such as sildenafil, anticoagulants (blood thinners), antidepressants, antipsychotics, diuretics, insulin, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
This is not a complete list of Cipro drug interactions, so discuss any medications you’re on, even if you don’t see them listed here. Cipro can cause low blood sugar in some patients. Be wary of low blood pressure symptoms such as blurred vision, fatigue, confusion, pale skin, and cold sweats. Watch for these adverse effects if you have diabetes, and take diabetes medication orally. These could be signs of hypoglycemia and could lead to unconsciousness.
The U. S. Food and Drug Administration (FDA) has found that, while rare, fluoroquinolone antibiotics like Cipro can increase the occurrence of severe ruptures or tears in your aorta (a large artery that begins in the heart). These ruptures can lead to dangerous aortic bleeding, a heart attack, or even death, so people at risk for cardiac problems should be cautious about taking Cipro.
Be sure to tell your doctor if you have been diagnosed with or have a history of other medical conditions, including a prolonged QT interval (a rare heart problem that may cause an irregular heartbeat, fainting, or sudden death), aneurysms, kidney disease, liver disease, heart disease, myasthenia gravis (severe muscle weakness), seizures, or diabetes. Cipro can also significantly increase theophylline levels in your blood, leading to serious illness or death. This is not a comprehensive list of medical conditions that Cipro may affect, so speak with your doctor about your medical history before taking Cipro.
Cipro can cause your skin to become sensitive to sunlight or ultraviolet light, so try to avoid unnecessary sun exposure and do your best to wear protective clothing, sunglasses, or sunscreen that is SPF 15 or higher. Call your doctor if you notice redness, swelling, or blistering from sun exposure while on Cipro.
As with all prescription medication, inform the prescribing doctor about any medical conditions you have been diagnosed with and any medications or supplements you currently take before starting treatment. Antacids can reduce the amount of Cipro that your body absorbs, so be sure to take them at least 2 hours before or 6 hours after taking antacid medications.
In addition, let your doctor know if you are breastfeeding, pregnant, or planning on becoming pregnant before starting treatment with this medication.
Contains Sulfamethoxazole and Trimethoprim.
Stade de France Pharmacy